Antidepressant Medication Adherence in Adults With Depression
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 2
- 主要终点
- Antidepressant adherence
研究概览
简要总结
The investigators will test using financial incentives by leveraging decision-making biases to improve adherence to antidepressants among adults newly prescribed antidepressants. This study will compare the effects of usual care, increasing financial incentives, and decreasing financial incentives on daily antidepressant medication adherence and depression symptom control of non-elderly adults with Major Depressive Disorder.
详细描述
A three arm randomized controlled trial will compare interventions to promote antidepressant adherence. One hundred twenty adults with major depressive disorder (MDD) who are initiating antidepressant treatment will be randomized in equal proportion to 1) usual care, 2) usual care and an escalating daily financial incentive for 6 weeks, or 3) usual care and a de-escalating financial incentive for daily antidepressant adherence for 6 weeks. Study patients will participate in three assessments over a 12 week period as well as passive monitoring of antidepressant daily adherence through a wireless electronic pill bottle over the same 12 week period. The primary outcome will be the number of antidepressant daily doses taken during the initial six weeks of treatment. The secondary outcome will be daily adherence during the next six weeks following the discontinuation of the intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 21 Years 至 64 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Prescribed antidepressant
- •Plan to take antidepressant as prescribed
- •Working cell phone that allows texting
- •Score on PHQ-9 ≥ 10
排除标准
- •No antidepressant use in last 90 days
- •Never been diagnosed with bipolar disorder, schizophrenia, or schizoaffective disorder
- •Not currently pregnant or breastfeeding
- •No other serious medical condition
研究组 & 干预措施
Escalating Incentives
Participants assigned to the escalating financial incentives will receive an increasing financial incentive for taking their antidepressant medication for the initial 6 weeks of treatment.
干预措施: Financial incentives (Other)
De-escalating Incentives
Participants assigned to the de-escalating financial incentives will receive a decreasing financial incentive for taking their antidepressant medication for the initial 6 weeks of treatment.
干预措施: Financial incentives (Other)
Control
Participants in this condition will receive usual care.
结局指标
主要结局
Antidepressant adherence
时间窗: Daily for first 6 weeks of study
The number of antidepressant daily doses taken during the initial six weeks of treatment
次要结局
- Depression symptoms(At baseline, 6 week follow-up, and 12 week follow-up)
- Antidepressant adherence post-intervention(Daily between 6 and 12 weeks)