TheEffect of pH on Misoprostol in Induction of Labor
- Conditions
- Labor Pain
- Interventions
- Registration Number
- NCT03829592
- Lead Sponsor
- Aljazeera Hospital
- Brief Summary
Misoprostol is a synthetic analogue of the naturally occurring prostaglandin E1. It was initially marketed for the treatment of peptic ulcers due to its mucosal protective and anti-secretory properties, but has commonly been used for the induction of abortion and labour .
- Detailed Description
Although initially having been established for oral use, misoprostol tablets are commonly used as vaginal suppositories for the previously purposes. Water or saline are frequently used in common practice to moisten the tablets prior to their administration, however, according to the pharmacokinetics of the drug, it should liquefy better in an acidic medium
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 180
- Singleton pregnancies. Gestational age 38-41 weeks. Cephalic presentation
-
- Multi-fetal pregnancy. 2. Pregnant women less than 38 weeks gestation.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Misoprostol in alkaline media misoprostol in an alkaline media Intervention : misoprostol in alkaline media will be given to induce labour misoprostol in neutral media misoprostol in a neutral media Intervention : misoprostol in a neutral media will be given to women to induce labour Misoprostol in acidic media misoprostol in an acidic media Intervention : misoprostol in acidic media will be given to induce labour
- Primary Outcome Measures
Name Time Method The number of women who will start lactive phase of labour after treatment within 24 hours the number of women in a group who will enter in active labour faster than other groups
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Algazeerah and Kasralainy hospital
🇪🇬Giza, Egypt
Algazeerah and Kasralainy hospital🇪🇬Giza, Egypt