Variation of Echocardiographic Parameters After Red Blood Cell Transfusion in Emergency Department Anemic Patients

Not Applicable

Recruiting

• Conditions: Anemia; Ultrasonography; Age Problem
• Interventions: Diagnostic Test: transthoracic echocardiography

• Registration Number: NCT06060639
• Lead Sponsor: Centre Hospitalier Universitaire de Nīmes

Brief Summary

The goal of this interventional study is to asses echocardiographic variations in emergency department's elderly patients receiving red blood cell transfusion. The main questions it aims to answer are :

* is there a modification of echocardiographic parameters after red blood cell transfusion ?

* which parameter is the most impacted by red blood cell transfusion ? Participants will have a transthoracic echocardiography before, just after and 15 minutes after red blood cell transfusion.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-09-25
• Study First Submitted QC: 2023-09-25
• Study First Posted: 2023-09-29
• Status Verified: 2023-11
• Study Start: 2023-11-09
• Last Update Submitted: 2023-11-23
• Last Update Posted: 2023-11-29
• Primary Completion: 2024-11-09
• Study Completion: 2024-11-09

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 116

Inclusion Criteria

• patient needing red blood cell transfusion
• consent
• social protection

Exclusion Criteria

• fluid filing over 500 mL of crystalloids
• transfusion in the last hour

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
transfused patients	transthoracic echocardiography	patients receiving red blood cell transfusion

Primary Outcome Measures

Name	Time	Method
E/A ratio modification	Base line, just after and 15 minutes after red blood cell transfusion	E/A ratio permits to estimate left ventricle pressure

Secondary Outcome Measures

Name	Time	Method
New York Heart Association scale (NYHA) modification	baseline and 24 hour after red blood cells transfusion	NYHA is a validated scale to asses patient dyspnea
E wave deceleration time	Base line, just after and 15 minutes after red blood cell transfusion	E wave deceleration time is a reflect of left atrium pressures
E/e' ratio modification	Base line, just after and 15 minutes after red blood cell transfusion	E/e' assesses left ventricle diastolic function
Lung score modification	Base line, just after and 15 minutes after red blood cell transfusion	Lung score permits to asses if extravascular water is present in lungs
Velocity-time Integral (VTI) modification	Base line, just after and 15 minutes after red blood cell transfusion	Aortic velocity-time integral is the reflect of cardiac output

Trial Locations

Locations (1)

CHU de Nîmes; 🇫🇷 Nîmes, Gard, France