Investigation of the brain pathophysiology of addiction disorder and evaluation of the treatment effect of neuromodulatio

Not Applicable

Recruiting

• Conditions: Mental and behavioral disorders

• Registration Number: KCT0002823
• Lead Sponsor: The Catholic University of Korea, Incheon St. Mary's Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 17 July 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

[Alcohol use disorder group]
(a) Diagnosed with alcohol use disorder based on the Diagnostic and Statistical Manual of Mental Disorders-5 and taking standard medication, and alcohol abstinence status will be considered.
(b) Adult men and women aged 20 to 60 years

[Problematic drinking group]
(a) More than 4 standard drinks (SD) for one occasion or more than 14 SD for one week (men) / More than 3 SD for one occasion or more than 7 SD for one week (women) or scores of 8 or more on Alcohol Use Disorders Identification Test (AUDIT) for men / scores of 6 of more on AUDIT for women
(b) Adult men and women aged 20 to 60 years

[Normal control group]
(a) Adult men and women aged 20 to 60 years

Exclusion Criteria

Exclusion criteria
(a) Have major medical, neurological, or psychiatric illnesses
(b) Pregnant, lactation, or have a pregnancy plan
(c) Not compatible for MRI and PET-CT (internal metal and medical devices, claustrophobia, etc.)
(d) History of seizures
(e) Problems with stimulation electrodes due to deformity of the scalp, inflammation reaction or other dermatological problems
(f) History of cancer in the past three years
(g) Surgery for brain vessels such as brain surgery or carotid surgery
(h) Dyspnea when sitting still
(i) Loss of consciousness for more than one hour due to other causes other than general anesthesia
(j) Have been hospitalized for a head injury

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Alcohol use disorder symptoms such as cravings assessed by self-report questionnaire;Maintenance of abstinence from alcohol

Secondary Outcome Measures

Name	Time	Method
Changes in structure, function, and metabolism of the brain evaluated using MRI and PET;Changes in depressive symptoms assessed by self-report questionnaire;Changes in anxiety symptoms assessed by self-report questionnaire;Changes in cognitive function evaluated by neuropsychological tests