Prospective analysis of clot stability and hyperfibrinolysis before and during liver transplantation using viscoelastometric tests and investigation of their predictive value with regard to intraoperative transfusion volumes and thromboembolic complications.

• Conditions: iver transplantation; K72; Hepatic failure, not elsewhere classified

• Registration Number: DRKS00032827
• Lead Sponsor: MU Klinikum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-10-06
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 31

Inclusion Criteria

Patients for orthotopic liver transplantation
- Consent of patient or caregiver
- Age > 18 years

Exclusion Criteria

- Refusal of the patient or caregiver.
- Age < 18 years
- Stop of the operation, e.g. due to rejection of the organ

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Detection of hyperfibrinolysis by viscoelastometry (EX-test and ECA-test) at the described measurement time points (before the start of surgery, immediately at the start of the anhepatic phase, at the end of the anhepatic phase, 10min after reperfusion, and at the end of surgery).

Secondary Outcome Measures

Name	Time	Method
1. Time to detection of hyperfibrinolysis.<br>2. Correlation of preoperative viscoelastometric variables with transfusion volumes<br>3. Correlation of preoperative coagulation factor concentrations with bleeding volumes<br>4. Correlation of viscoelastometric variables with occurrence of thromboembolic events within 7 days postoperatively.