Comparison of two palliative hypofractionated Radiotherapy schedules in patients of advanced Head and Neck Squamous cell Carcinoma - a single institutional prospective randomized study.

I0 个研究点目标入组 0 人开始时间: 待定最近更新: 2024年6月24日

试验速览

暂无简介。

•Age between 18 to 80 years
•-Histopathologically diagnosed as squamous cell carcinoma
•-Cancer of head and neck involving the following sub-sites:-
•o Oral cavity
•o Oropharynx
•o Hypo-pharynx
•-De-novo or recurrent / refractory cases
•-Clinically stage group III to IVC (AJCC 8th Edition)
•-ECOG PS 0 to 3
•-Deemed unsuitable for surgery / inoperable in a multidisciplinary tumour board
•-Calculated life expectancy > 90 days
•-Baseline Haemoglobin >9 gm/dl, ANC > 1500/µl, platelets > 1,00,000/µl
•-Creatinine Clearance >30 ml/min
•-Written informed consent

•-Histopathology other than squamous cell carcinoma
•-Pregnancy and lactation
•-Uncontrolled severe comorbidities
•-Severe dyselectrolytaemia
•-Sub-sites other than Oral cavity, Oropharynx, Hypo-pharynx and Larynx
•-Major psychiatric illness making the patient incapable of following medical advice
•-Prior head and neck radiotherapy within the last 6 months
•-Prior head and neck surgery within the last 3 months
•-Concomitant or prior chemotherapy / targeted therapy / immunotherapy within the last 2
•-Inability to receive palliative radiotherapy due to patient’s clinical condition, positional
•or immobilization issues or other reasons
•-Unwillingness to undergo palliative radiotherapy
•-Refusal to provide informed consent

发起方