Interstitial Lung Disease and Obstructive Sleep Apnea

Recruiting

• Conditions: ILD OSA
• Interventions: Diagnostic Test: The relationship between imaging and ROSE and NGS

• Registration Number: NCT05838183
• Lead Sponsor: Dan Liu

Brief Summary

Clinically, all patients with interstitial lung disease(ILD) were observed, and relevant clinical data were collected. Bronchoscopic specimens were collected according to the condition of the enrolled patients, and the rapid on site evaluation(ROSE) was evaluated, combined with the metagenomic next generation sequencing(mNGS) results of these patients. To observe the etiology and biological characteristics of exacerbation in patients with interstitial lung disease.

All patients undergo polysomnography (PSG) and drug-induced sleep endoscopy(DISE). The biological specimens was obtained for molecular biology or other tests.We detected Claudin1, Claudin2, Claudin3, Claudin4, and IL22 as biomarkers to differentiate the diagnostic efficiency of OSA in ILD, ILD+OSA, OSA, and Ctrl groups, respectively

Detailed Description

Not available

Study Timeline

• Study Start: 2019-09-01
• Study First Submitted: 2023-04-10
• Study First Submitted QC: 2023-04-20
• Study First Posted: 2023-05-01
• Status Verified: 2024-12
• Last Update Submitted: 2025-01-18
• Last Update Posted: 2025-01-22
• Primary Completion: 2025-08-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
OSA group	The relationship between imaging and ROSE and NGS	Sleep detection was performed in OSA patients，And according to the severity of the analysis, obtain the corresponding biological specimens, the relevant detection
Interstitial lung disease group	The relationship between imaging and ROSE and NGS	Bronchoscopy was performed to obtain alveolar lavage fluid in ILD patients and lung tissue was obtained for ROSE and NGS in appropriate patients

Primary Outcome Measures

Name	Time	Method
imaging changes and ROSE and NGS in patients	2Day	Relationship between imaging changes and ROSE and NGS in patients with interstitial lung disease

Secondary Outcome Measures

Name	Time	Method
Severity and biological examination of OSA patients	2Day	Classification of the severity of OSA and the relationship between positive results of biological or other tests

Trial Locations

Locations (1)

Tianjin Medical University General Hospital; 🇨🇳 Tianjin, China