Comparison of the Tissue Trauma Markers Following Total Laparoscopic Hysterectomy vs Total Abdominal Hysterectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 主要终点
- Pentraxin-3 level
研究概览
简要总结
Comparison of the Tissue Trauma Markers Following Total Laparoscopic Hysterectomy vs Total Abdominal Hysterectomy
详细描述
Acute trauma and major surgeries activate a series of cascades to evoke systemic inflammatory response. The magnitude of the resulting inflammatory response is proportional to the severity of the tissue trauma. Abdominal or laparoscopic technique is widely used for the purpose of hysterectomy surgery. It is crucial for many aspects to compare these two techniques of hysterectomy in terms of the surgery-induced trauma.
In this study, the severity of the inflammatory response resulting from the tissue trauma due to the techniques of TLH+BSO and TAH+BSO applied in our department were compared based on the PTX-3 molecule.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •·TLH+BSO patients and TAH+BSO patients
排除标准
- •History of a chronic disease (coronary artery disease, diabetes mellitus, hypertension, coronary liver failures, chronic kidney disease, chronic respiratory diseases, connective tissue disorders) which may affect levels of PTX-3 and other inflammatory markers.
- •Prior surgery due to malignancy.
- •History of an intra-abdominal surgery, except for cesarean section.
- •History of any disease which may lead to intra-abdominal adhesions (endometriosis, past pelvic infection).
结局指标
主要结局
Pentraxin-3 level
时间窗: Before 24 hours preoperatively and upto 24 hours postoperatively
Pentraxin-3 ng/mL
次要结局
- (NLR)(Up to 24 hours postoperative)
研究者
Burak Sezgin
Principal Investigator
Muğla Sıtkı Koçman University