Evaluation of Immunoregulatory Cells in Hematopoietic Stem Cell Transplant

Completed

• Conditions: Hematopoietic Stem Cell Transplantation; Graft vs Host Disease

• Registration Number: NCT00179049
• Lead Sponsor: Vanderbilt University

Brief Summary

The investigators' hypothesis is that the graft-versus-tumor effect can be enhanced while minimizing the complications of graft-versus-host disease.

Detailed Description

The investigators' hypothesis is that the graft-versus-tumor effect can be enhanced while minimizing the complications of graft-versus-host disease (GVHD) by determining the qualitative and quantitative changes in T regulatory cells throughout the transplant process. Their understanding of this can lead to new treatment strategies and improved clinical therapeutic implications.

Study Timeline

• Study Start: 2003-04
• Study First Submitted: 2005-09-13
• Study First Submitted QC: 2005-09-13
• Study First Posted: 2005-09-15
• Study Completion: 2008-04
• Status Verified: 2008-12
• Last Update Submitted: 2008-12-12
• Last Update Posted: 2008-12-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patients 18-70 years old undergoing either autologous transplant or allogeneic transplant for various hematologic conditions

Exclusion Criteria

• Patients < 18 or > 70 years old undergoing either autologous transplant or allogeneic transplant

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Vanderbilt University Medical Center; 🇺🇸 Nashville, Tennessee, United States