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临床试验/NCT05864586
NCT05864586已完成不适用

Nicotine Concentration and Forms: Differential Appeal to Smokers Versus Non-Smokers

Ohio State University Comprehensive Cancer Center1 个研究点 分布在 1 个国家目标入组 150 人开始时间: 2023年5月30日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
150
试验地点
1
主要终点
Degree of Liking or Disliking of Sensations

研究概览

简要总结

The Sweet Spot Study aims to evaluate the effect of e-liquids with nicotine varying in freebase (FB) levels and concentrations on the appeal of electronic cigarettes (ECs) in young adult EC users with minimal/no history of smoking and older adult smokers.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Factorial
主要目的
Prevention
盲法
Double (Participant, Investigator)

入排标准

年龄范围
21 Years 至 50 Years(Adult)
性别
All
接受健康志愿者
是

入选标准

  • •Young adult e-cigarette user or older adult smoker
  • •Willing to abstain from all nicotine product use for 12 hours prior to the study visit
  • •Read and speak English

排除标准

  • •Currently attempting to quit nicotine products
  • •Currently pregnant, planning to become pregnant, or breastfeeding
  • •Current or past use of tobacco products other than e-cigarettes or cigarettes
  • •Self-reported diagnosis of lung disease
  • •Self-reported new or unstable cardiovascular disease

研究组 & 干预措施

Young adult EC users

Active Comparator

Young Adult EC users

干预措施: Vaping study EC I (Behavioral)

Young adult EC users

Active Comparator

Young Adult EC users

干预措施: Vaping study EC J (Behavioral)

Older adult smokers

Active Comparator

Adult smokers

干预措施: Vaping study EC A (Behavioral)

Older adult smokers

Active Comparator

Adult smokers

干预措施: Vaping study EC B (Behavioral)

Older adult smokers

Active Comparator

Adult smokers

干预措施: Vaping study EC C (Behavioral)

Young adult EC users

Active Comparator

Young Adult EC users

干预措施: Vaping study EC H (Behavioral)

Young adult EC users

Active Comparator

Young Adult EC users

干预措施: Vaping study EC F (Behavioral)

Young adult EC users

Active Comparator

Young Adult EC users

干预措施: Vaping study EC G (Behavioral)

Young adult EC users

Active Comparator

Young Adult EC users

干预措施: Vaping study EC A (Behavioral)

Young adult EC users

Active Comparator

Young Adult EC users

干预措施: Vaping study EC B (Behavioral)

Young adult EC users

Active Comparator

Young Adult EC users

干预措施: Vaping study EC C (Behavioral)

Young adult EC users

Active Comparator

Young Adult EC users

干预措施: Vaping study EC D (Behavioral)

Young adult EC users

Active Comparator

Young Adult EC users

干预措施: Vaping study EC E (Behavioral)

Older adult smokers

Active Comparator

Adult smokers

干预措施: Vaping study EC D (Behavioral)

Older adult smokers

Active Comparator

Adult smokers

干预措施: Vaping study EC E (Behavioral)

Older adult smokers

Active Comparator

Adult smokers

干预措施: Vaping study EC F (Behavioral)

Older adult smokers

Active Comparator

Adult smokers

干预措施: Vaping study EC G (Behavioral)

Older adult smokers

Active Comparator

Adult smokers

干预措施: Vaping study EC H (Behavioral)

Older adult smokers

Active Comparator

Adult smokers

干预措施: Vaping study EC I (Behavioral)

Older adult smokers

Active Comparator

Adult smokers

干预措施: Vaping study EC J (Behavioral)

结局指标

主要结局

Degree of Liking or Disliking of Sensations

时间窗: The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours.

Self-report measure completed following e-cigarette self-administration, using the Labeled Hedonic Scale (LHS). Scores range from -100 (most disliked imaginable) to 100 (most liked imaginable) with higher scores indicating a greater degree of liking.

Behavioral Intentions for Continued Use

时间窗: The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours.

Self-report measure on a 7-point scale completed following e-cigarette self-administration. Ratings range from1 (extremely unlikely) to 7 (extremely likely) with higher scores indicating a higher likelihood of continuing to use the product.

Intensity of Sensory Attributes

时间窗: The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours.

5-item self-report measure completed following e-cigarette self-administration, using the general Labeled Magnitude Scale (gLMS). Scores range from 0 (no sensation) to 100 (strongest imaginable) with higher scores indicating a greater sensation intensity.

次要结局

  • Subjective Appeal(The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours.)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Theodore Wagener

Principal Investigator

Ohio State University Comprehensive Cancer Center

研究点 (1)

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