Developing E-liquid Product Standards (Sweet Spot Study)

Not Applicable

Completed

• Conditions: Nicotine; E-cigarette Use; Nicotine Vaping
• Interventions: Behavioral: Vaping study EC A; Behavioral: Vaping study EC B; Behavioral: Vaping study EC C; Behavioral: Vaping study EC D; Behavioral: Vaping study EC E; Behavioral: Vaping study EC F; Behavioral: Vaping study EC G; Behavioral: Vaping study EC H; Behavioral: Vaping study EC I; Behavioral: Vaping study EC J

• Registration Number: NCT05864586
• Lead Sponsor: Ohio State University Comprehensive Cancer Center

Brief Summary

The Sweet Spot Study aims to evaluate the effect of e-liquids with nicotine varying in freebase (FB) levels and concentrations on the appeal of electronic cigarettes (ECs) in young adult EC users with minimal/no history of smoking and older adult smokers.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-05-09
• Study First Submitted QC: 2023-05-09
• Study First Posted: 2023-05-18
• Study Start: 2023-05-30
• Primary Completion: 2024-02-26
• Study Completion: 2024-02-26
• Results First Submitted: 2025-01-17
• Status Verified: 2025-03
• Results First Submitted QC: 2025-03-21
• Last Update Submitted: 2025-03-21
• Results First Posted: 2025-04-10
• Last Update Posted: 2025-04-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Young adult EC users	Vaping study EC B	Young Adult EC users
Young adult EC users	Vaping study EC C	Young Adult EC users
Young adult EC users	Vaping study EC G	Young Adult EC users
Young adult EC users	Vaping study EC H	Young Adult EC users
Older adult smokers	Vaping study EC B	Adult smokers
Older adult smokers	Vaping study EC F	Adult smokers
Older adult smokers	Vaping study EC D	Adult smokers
Older adult smokers	Vaping study EC H	Adult smokers
Young adult EC users	Vaping study EC E	Young Adult EC users
Young adult EC users	Vaping study EC I	Young Adult EC users
Older adult smokers	Vaping study EC A	Adult smokers
Young adult EC users	Vaping study EC A	Young Adult EC users
Young adult EC users	Vaping study EC D	Young Adult EC users
Young adult EC users	Vaping study EC F	Young Adult EC users
Young adult EC users	Vaping study EC J	Young Adult EC users
Older adult smokers	Vaping study EC C	Adult smokers
Older adult smokers	Vaping study EC G	Adult smokers
Older adult smokers	Vaping study EC J	Adult smokers
Older adult smokers	Vaping study EC E	Adult smokers
Older adult smokers	Vaping study EC I	Adult smokers

Primary Outcome Measures

Name	Time	Method
Behavioral Intentions for Continued Use	The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours.	Self-report measure on a 7-point scale completed following e-cigarette self-administration. Ratings range from1 (extremely unlikely) to 7 (extremely likely) with higher scores indicating a higher likelihood of continuing to use the product.
Intensity of Sensory Attributes	The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours.	5-item self-report measure completed following e-cigarette self-administration, using the general Labeled Magnitude Scale (gLMS). Scores range from 0 (no sensation) to 100 (strongest imaginable) with higher scores indicating a greater sensation intensity.
Degree of Liking or Disliking of Sensations	The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours.	Self-report measure completed following e-cigarette self-administration, using the Labeled Hedonic Scale (LHS). Scores range from -100 (most disliked imaginable) to 100 (most liked imaginable) with higher scores indicating a greater degree of liking.

Secondary Outcome Measures

Name	Time	Method
Subjective Appeal	The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours.	12-item modified Cigarette Evaluation Questionnaire (mCEQ) completed following e-cigarette self-administration to assess subjective responses to the e-cigarettes. The 12-item mCEQ includes five subscales: Smoking Satisfaction, Psychological Reward, Aversion, Enjoyment of Respiratory Tract Sensations, and Craving Reduction, with items rated from 1 (not at all) to 7 (extremely likely). Scores for each subscale are calculated as the mean of the individual item responses or the single item. Higher scores indicate greater intensity on that scale.

Trial Locations

Locations (1)

Ohio State University Comprehensive Cancer Center; 🇺🇸 Columbus, Ohio, United States