Risk Markers of Arterial Aging. The Paris Prospective Study III-2
- Conditions
- Arterial Stiffness
- Interventions
- Other: high-precision carotid echo-tracking
- Registration Number
- NCT06079424
- Lead Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
- Brief Summary
The main objectives of PPS3-2 are (i) to describe the dynamics of vascular aging and baroreflex sensitivity 12 to 16 years a part, (ii) to identify their determinants, and (iii) to quantify the subsequent risk of cardiovascular diseases.
- Detailed Description
Since May 2008, PPS3 is being following the CVD morbidity of 10157 healthy volunteers aged 50-75 years at baseline. In PPS3-2, we plan to re-invite survivors and volunteers of PPS3 to undergo a second physical examination. In particular, they will undergo a second high-precision carotid echotracking to measure vascular aging parameters and baroreflex sensitivity, permitting to study their respective dynamics. They will also underwent for the first time ultra fast echo of the radial artery to measure vascular aging parameters of the medium-sized arteries. According to fundings, blood samples will be taken and stored at -80°C in the whole population or in a subsample.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 7500
- Being enrolled in PPS3 and having signed an informed consent for PPS3-2
- Institutionalized participants
- Participants under guardianship
- Participants under judicial safeguard measure
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Level of vascular aging high-precision carotid echo-tracking community-based prospective longitudinal cohort
- Primary Outcome Measures
Name Time Method carotid diameter by 2027 high precision carotid echo tracking diameter in mm
intima media thickness by 2027 high precision echo tracking intima media thickness of the common carotid artery in mm
carotid plaques by 2027 high precision carotid echo tracking carotid plaques
elastic modulus by 2027 high precision carotid echo tracking Young's elastic modulus, 10-3\*kPa
pulse wave velocity by 2027 high precision carotid echotracking pulse wave velocity, m/s
carotid wall stress by 2027 high precision carotid echotracking circumferential wall stress in kPa
wall cross sectional area by 2027 high precision carotid echo tracking carotid wall cross sectional area, mm2
pulse pressure by 2027 high precision carotid echotracking pulse pressure in mmHg
distensibility coefficient by 2027 high precision carotid echo tracking distensibility coefficient in 10-3/kPa
stiffness by 2027 high precision carotid echotracking Beta stiffness index
- Secondary Outcome Measures
Name Time Method wall cross sectional area of the radial artery by 2027 ultra high frequency ultrasound radial artery wall cross sectional area, mm2
brachial artery diameter by 2027 ultra high frequency ultrasound radial artery diameter in mm
thickness of the intima media of the radial artery by 2027 ultra high frequency ultrasound radial artery intima media thickness in mm
distensibility of the radial artery by 2027 ultra high frequency ultrasound radial artery distensibility coefficient in 10-3/kPa
wall stress of the radial artery by 2027 ultra high frequency ultrasound radial artery Circumferential wall stress, kPa
arterial plaques by 2027 ultra high frequency ultrasound radial artery plaques
elastic modulus of the radial artery by 2027 ultra high frequency ultrasound radial artery Young's elastic modulus, 10-3\*kPa
pulse wave velocity of the radial artery by 2027 ultra high frequency ultrasound radial artery Pulse wave velocity, m/s
stiffness index of the radial artery by 2027 ultra high frequency ultrasound radial artery Beta stiffness index
pulse pressure of the radial artery by 2027 ultra high frequency ultrasound radial artery Pulse Pressure, mmHg