A randomised trial of a Lung-Open Ventilation Strategy in acute lung injury

McMaster University (Canada)0 sites980 target enrollmentAugust 11, 2005

Overview

No summary available.

Registry

who.int

Start Date

August 11, 2005

End Date

TBD

Last Updated

11 years ago

Study Type

Interventional

Sex

All

Sponsor

McMaster University (Canada)

•Persons of either sex 18 years and older.
•1\. Invasive mechanical ventilation
•2\. Acute respiratory insufficiency (within past 28 days)
•3\. Bilateral infiltrates on frontal chest radiograph
•4\. Hypoxemia, defined as paO2/FiO2 less than or equal to 250, on any amount of Positive End\-Expiratory Pressure (PEEP)

•1\. Primary cause of respiratory failure is cardiac
•2\. Anticipated duration of mechanical ventilation \<48 hours, as judged by the intensivist
•3\. Inability to wean from other experimental ventilation strategies
•4\. Severe chronic respiratory disease
•5\. Neuromuscular disease that will result in prolonged need for mechanical ventilation
•6\. Conditions where hypercapnia\-induced intracranial hypertension should be avoided
•7\. Morbid obesity (\>1 kg per cm body weight)
•8\. Pregnancy
•9\. Very unlikely to survive in the judgment of the investigator, and luck of commitment to life support
•10\. Malignancy or underlying irreversible condition with 6 month mortality greater than or equal to 50%