Treatment outcome analysis of febrile patients with cytopenia according to the cytotoxicity of natural-killer and cytotoxic T-cell, and the level of natural-killer cell activation induced interferon-gamma
Not Applicable
Completed
- Conditions
- Diseases of the blood and blood -forming organs and certain disorders involving the immune mechanism
- Registration Number
- KCT0001886
- Lead Sponsor
- The Catholic University of Korea, Seoul St. Mary's Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 130
Inclusion Criteria
1) Adult (15 years or older ) patients
2) Fever (=38 degree centigrade) calculated by tympanic temperature
3) Patients who shows hemophagocytosis in bone marrow sample (also satisfying 1) and 2) above)
4) Patients who shows cytopenias at least 2 lineages (also satisfying 1) and 2) above)
Exclusion Criteria
Exclusion criteria
1) Patients who were treated with intensive chemotherapy within 3 months before screening
2) Patients who were already diagnosed as immune thrombocytopenic purpura before
3) Patients who were alreadydiagnosed as autoimmune hemolytic anemia or chronic anemia before
4) Patients who were previously diagnosed as aplastic anemia before
Study & Design
- Study Type
- Observational Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Measuring cytotoxic function of natural killer (NK) cells and the level of NK cell induced interferon gamma, and identification of overall survival according to the levels.
- Secondary Outcome Measures
Name Time Method The cytotoxic function and interferon-gamma level differences according to the causes of disease;Treatment response according to the cytotoxic function of NK cells and the level of NK cell induced interferon gamma