Identification, in Patients Admitted to Intensive Care for Severe Influenza Respiratory Infection, of a Predictive Biomarker of Respiratory Distress
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 227
- 试验地点
- 22
- 主要终点
- Change in ratio of the partial pressure of oxygen in arterial blood (PaO2) to the inspired oxygen fraction (FiO2), from admission at 7 days post-admission
研究概览
简要总结
Influenza is a major cause of morbidity and mortality. The investigators first goal is to evaluate soluble HLA-G5 isoform serum level as a potential marker of greater risk of death from Influenza respiratory illness in adult and pediatric patients hospitalized in reanimation. Secondly, the investigators collected respiratory samples in order to study the transcriptomic profiles of influenza-infected patients with severe symptoms.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 1 Month 至 99 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient (Adult or Pediatric)
- •Hospitalized in reanimation
- •With a laboratory confirmed Influenza
- •That agree to take part in the study
- •Affiliated to National Health Insurance
- •For ancillary group :
- •Adult at least 60 years old
- •Presenting at hospital for a blood test
排除标准
- •non willing to participate
- •Influenza infection with no respiratory symptoms
- •pregnancy
- •For ancillary group :
- •Presence of immunodepression defined by:
- •Cancer, or cancer cured for less than 2 years
- •Corticosteroids, Methotrexate (MTX), anti Tumor Necrosis Factor (TNF), anti-CD20
- •Infection in progress (fever)
研究组 & 干预措施
influenza cohort
Influenza is a major cause of morbidity and mortality. The investigators' first goal is to evaluate soluble HLA-G5 isoform serum level as a potential marker of greater risk of death from Influenza respiratory illness in adult and pediatric patients hospitalized in reanimation.
1 control group of 30 patients (ancillary study) will be constitued to have reference values of the HLA-G5 marker.
Secondly, the investigators collected respiratory samples in order to study the transcriptomic profiles of influenza-infected patients with severe symptoms.
干预措施: influenza cohort (Other)
结局指标
主要结局
Change in ratio of the partial pressure of oxygen in arterial blood (PaO2) to the inspired oxygen fraction (FiO2), from admission at 7 days post-admission
时间窗: The first, third, fifth and seventh day of hospitalization in reanimation
decreased arterial PaO2/FiO2 ratio ≤ 100 mmHg (≤ 13.3 kPa)
次要结局
- All cause mortality(90 days after hospitalization)
- Extracorporeal membrane oxygenation requirement(90 days after hospitalization)
- SOFA score (Adult) PELOD (Pediatric)(The first, third, fifth and seventh day of hospitalization in reanimation)