临床试验/NCT04966975

NCT04966975Unknown不适用

Effect and Prognosis of Immunohistochemical Biomarkers Changes in Patients With Bladder Cancer After Neoadjuvant Chemotherapy

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University0 个研究点目标入组 60 人开始时间: 2021年9月1日最近更新: 2021年7月19日

适应症

试验速览

阶段: 不适用
发起方: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
入组人数: 60
主要终点: Tumor regression grade

研究概览研究设计入排标准结局指标研究者记录与标识符相似试验

研究概览

简要总结

Clinical trial to investigate the relationship between the expression of immunohistochemical biomarkers GATA-3, CK20, P53 and Ki67 in bladder cancer and pathological complete response after neoadjuvant chemotherapy.

详细描述

This is a retrospective study included bladder cancer patients treated with neoadjuvant chemotherapy. We analyzed the changes in the expression of GATA-3, CK20, P53 and Ki67 before and after NAC. Evaluating the sensitivity factor for predicting pathological complete response.

研究设计

研究类型: Observational
观察模型: Cohort
时间视角: Prospective

入排标准

年龄范围: 18 Years 至 80 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Any male or female patient aged 18 or older.
•Histologically confirmed bladder cancer, cystectomy was performed after NAC.
•Complete clinical data.

排除标准

•Patients with severe organic disease who can not tolerate chemotherapy or surgery
•Patients received previous treatment (chemotherapy, radiation, or molecular targeted therapy).
•Patients with distant metastasis or other cancer history.

结局指标

主要结局

Tumor regression grade

时间窗: 1 year

Expression of immunohistochemical biomarkers GATA-3, CK20, P53 and Ki67

时间窗: 1 year

次要结局

未报告次要终点

研究者

发起方

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

申办方类型

Other

责任方

Sponsor

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