Comparative Microarray Analysis in Primary Cutaneous Malignant Melanoma

Completed

• Conditions: Cutaneous Malignant Melanoma
• Interventions: Procedure: Biopsy

• Registration Number: NCT01482260
• Lead Sponsor: Ruhr University of Bochum

Brief Summary

Perturbations in microRNA (miRNA) expression profiles has been reported for cutaneous malignant melanoma (CMM). This study will be an exploratory analysis by miRNA expression profiling using microarrays.

Detailed Description

Perturbations in microRNA (miRNA) expression profiles has been reported for cutaneous malignant melanoma (CMM). With regards to a rapidly growing number of newly discovered miRNA sequences, the availability of up-to-date miRNA expression profiles for primary cutaneous malignant melanoma (PCMM), cutaneous malignant melanoma metastases (CMMM) and benign melanocytic naevi (BMN) is limited. Patients with PCMM, CMMM and BMN are included in the study to perform an exploratory analysis by miRNA expression profiling using microarrays. Expression levels of miRNA candidates will be validated by TaqMan real-time quantitative polymerase chain reaction (RT-PCR).

Study Timeline

• Study First Submitted: 2011-11-26
• Study First Submitted QC: 2011-11-29
• Study First Posted: 2011-11-30
• Study Start: 2011-12
• Primary Completion: 2012-01
• Status Verified: 2012-11
• Last Update Submitted: 2012-11-05
• Last Update Posted: 2012-11-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

• Primary Cutaneous Malignant Melanoma
• Cutaneous Malignant Melanoma Metastases
• Benign Melanocytic Naevi

Exclusion Criteria

• Other Skin Cancer than Primary Cutaneous Malignant Melanoma

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Benign Melanocytic Nevi	Biopsy	-
Primary Cutaneous Malignant Melanoma	Biopsy	-
Cutaneous Malignant Melanoma Metastases	Biopsy	-

Trial Locations

Locations (1)

Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum; 🇩🇪 Bochum, NRW, Germany