Influence of CPB and Mini CPB to the Absorption of the Metoprolol
- Conditions
- Drug Absorption
- Interventions
- Drug: blood concentration of metoprolol
- Registration Number
- NCT01728272
- Lead Sponsor
- Kuopio University Hospital
- Brief Summary
Influence of perfusion, miniperfusion and off pump coronary artery bypass grafting to the absorbtion of metoprolol postoperatively, hypothesis in that miniperfusion and off pump surgery does not decrease absorbtion of the metoprolol compared to conventional pefusion.
- Detailed Description
Influence of perfusion, miniperfusion and off pump coronary artery bypass grafting to the absorbtion of metoprolol postoperatively, hypothesis in that miniperfusion and off pump surgery does not decrease absorbtion of the metoprolol compared to conventional pefusion.
Blood samples for concentration of metoprolol are taken preoperaively, 1. and 3. day after operation, before and 10 times after intake of 50 mg metoprolol.
Sudy is randomized into 3 groups: 1. Miniperfusion n.15 2. Perfusion n.15 3. offpump n.15
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 45
elective CABG patient -
contraindication to metoprolol
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description blood concentration of metoprolol blood concentration of metoprolol how does off-pump miniperfusion and perfusion CABG influence the absorption of metoprolol after CABG
- Primary Outcome Measures
Name Time Method absorbtion of the metoprolol one year absorbtion of the metoprolol, blood samples are taken centrifuged, frozed and analyzed
- Secondary Outcome Measures
Name Time Method atrial fibrillation one year is there correlation of incidence of the postopeative AF and absorbtion of the metoprolol
Trial Locations
- Locations (1)
Kuopio University Hospital
🇫🇮Kuopio, Finland