NCT01240018已完成不适用
Probiotics and Satiety - Acute Effects and Persistence of Acute Effects
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- Glucose, insulin, GLP-1, GLP-2, CCK, PYY, PP, ghrelin, amylin, LPS, TNF-alfa, CRP, fibrinogen.
研究概览
简要总结
The aim of the ProSat study is to examine the effects of a probiotic capsule containing Lb. Casei on subjective appetite sensation, ad libitum energy intake, and appetite hormone response in a single meal test and to determine whether the acute effects persist after daily supplementation of the probiotic capsule.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Healthy men and women
- •Normal to slight overweight (BMI: 22-28 kg/m2)
- •20-45 years of age
排除标准
- •Daily medicine use (oral contraceptives excluded)
- •Use of pre- and probiotic supplements and foods
- •Blood donation 3 months prior to the study
- •Hb < 7,5mmol/l
- •Chronic illnesses such as hyperlipidemia, diabetes inflammatory diseases
- •Pregnancy or breastfeeding
- •Elite athletes (>10 hours hard exercise/week)
- •Vegetarians
研究组 & 干预措施
High dose Lb. casei
Active Comparator
干预措施: Probiotic (Dietary Supplement)
Placebo
Placebo Comparator
干预措施: Probiotic (Dietary Supplement)
结局指标
主要结局
Glucose, insulin, GLP-1, GLP-2, CCK, PYY, PP, ghrelin, amylin, LPS, TNF-alfa, CRP, fibrinogen.
时间窗: June 2011
次要结局
- Subjective appetite measurements, spontaneous food intake.(June 2011)
研究者
AAstrup
Professor
University of Copenhagen
研究点 (1)
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