Effect of prebiotic fibres on Intestinal Health and Functioning - Prebiotics and metabolism

Medisch Universitair Ziekenhuis Maastricht0 sites48 target enrollmentTBD

Overview

No summary available.

Registry

who.int

Start Date

TBD

End Date

December 16, 2016

Last Updated

last year

Study Type

Interventional

Sponsor

Medisch Universitair Ziekenhuis Maastricht

•\- Healthy, normal/overweight men and women (BMI \* 20 kg/m2 \<30kg/m2\)
•\- Aged 20\-55 years
•\- Caucasian
•\- Normal fasting glucose (\<6\.1 mmol/L.)
•\- Normal blood pressure (systolic blood pressure 100\-140 mmHg, diastolic blood pressure 60\-90 mmHg)
•\- Weight stable in last 3 months (±2 kg)
•\- A low defecation frequency, \<4 times/week and no constipation or underlying pathology
•\- A slow gastro\-intestinal transit (\> 50th percentile based on Sadik et al. 2003, 2004\)

•\- Woman lactating, pregnant or (post)\-menopausal
•\- Regular smokers
•\- People with intensive fitness training, eg. athletes (\*3 per week \* 1 hour training)
•\- Diabetes Mellitus (defined as FPG \* 7\.0 mmol/l and or 2h PG \* 11\.1 mmol/l)
•\- Gastro\-intestinal diseases or abdominal surgery, cardiovascular diseases, cancer, liver or kidney malfunctioning, disease with a life expectation shorter than 5 years.
•\- Following a hypocaloric diet
•\- Gluten intolerance
•\- Regular use of laxation products, or use of antibiotics, probiotics or prebiotics 3 months prior to the start of the study
•\- Current use of medication interfering with study intervention or interfering with study endpoints/hypotheses
•\- Not to be able to understand the study information