Potential Associated Factors of Uncontrolled Hypertension

• Conditions: Hypertension,Essential

• Registration Number: NCT02723643
• Lead Sponsor: Guangdong Provincial People's Hospital

Brief Summary

The incidence and prevalence of hypertension is increasing while the controlled rate is extremely low in China. A substantial percentage of participants with uncontrolled hypertension are correctable if potential associated factors are identified and corrected. Therefore, it is clinically relevant to investigate and identify these potential associated factors of uncontrolled hypertension so as to increase controlled rate and reduce hypertension-associated health and economic burdens in the future. Investigators plan to conduct a prospective registry study in a single-center to initially investigate the potential associated factors of uncontrolled hypertension in cardiovascular outpatient department. Furthermore, investigators plan to evaluate the effects of potential associated factors correction on hypertension controlled rate and cardiovascular outcomes.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-01
• Status Verified: 2016-03
• Study First Submitted: 2016-03-18
• Study First Submitted QC: 2016-03-29
• Last Update Submitted: 2016-03-29
• Study First Posted: 2016-03-30
• Last Update Posted: 2016-03-30
• Primary Completion: 2018-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 2000

Inclusion Criteria

• Clinic systolic and/or diastolic blood pressure above 140 and/or 90 mm Hg treating with 3 different classes of anti-hypertensive drugs (not necessarily including diuretic).

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Exclusion Criteria

• Known secondary hypertension,
• Pregnant women,
• Chronic kidney disease (CKD) 3 or higher,
• Has a history of connective tissue diseases,
• Has a history of any type of cancer,
• Cognitive disorder which could not finish home blood pressure monitoring,
• Has a history of coronary heart disease,ischemic stroke,transient ischemic attack or heart failure.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Hypertension controlled rate in participants after potential associated factors are corrected	Up to 1 month	Participants with uncontrolled hypertension (SBP and/or DBP \>=140 and/or 90 mm Hg) treating with 3 or more anti-hypertensive drugs (not necessarily including diuretic) in outpatient department will under assessment of hypertension controlled rate 1 month later after initial investigation of potential associated factors. Based on these findings, investigators will give instructions to participants how to correct those potential associated factors and follow-up participants via telephone or outpatient visit 1 month later to assess whether these corrections could help increase hypertension controlled rate. Participants will be required to record home blood pressure measurements every day, and average home SBP and DBP will be calculated 1 month later. If average home SBP/DBP \< 135/85 mm Hg then participants will be considered as controlled-case, otherwise uncontrolled case.

Trial Locations

Locations (1)

Guangdong Cardiovascular Institute,Guangdong General Hospital; 🇨🇳 Guangzhou, Guangdong, China