Building vascular cognitive impairment cohort for development of a dementia risk assessment system and identification of pathophysiologycal interaction between vascular aging and neurodegeneration.

Gachon University Gil Medical Center0 个研究点目标入组 360 人开始时间: 待定最近更新: 2023年9月18日

试验速览

暂无简介。

•Cognitively Normal (CN)
•Normal cognition will be defined according to neuropsychological testing, which didn't fall within 1.5 SD, and Clinical Dementia Rating (CDR) was 0 .
•- Mild cognitive impairment (MCI):
•CDR was 0.5
•Subjects were not be clinically diagnosed with dementia according to Diagnostic and Statistical Manual of Mental Disorders, 4th. Edition, Text-revision (DSM-IV-TR) criteria.
•- Dementia (AD and SVaD)
•- Alzheimer's disease (AD)
•CDR = 0.5
•subjects were diagnosed with dementia according to DSM-IV-TR.
•subjects were diagnosed with probable AD or possible AD according to the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and Related Disorders Association (NINCDS-ADRDA) criteria.
•- Subcortical vascular dementia (SVaD)
•CDR = 0.5
•Subjects were diagnosed with vascular dementia according to DSM-IV-TR.
•In FLAIR images, whitematter hyperintensity was more than moderate according to the modified Fazeka’s scale.

•- Subjects who do not meet the inclusion criteria.
•- Subjects who have history of any significant neurological disease other than AD or VD , such as traumatic brain injury, Parkinson's disease, Huntington's disease, motor neuron disease, or multiple sclerosis.
•- Subjects who have history of brain tumor, normal presure hydrocephalus, encephalitis, or metabolic encephalopathy.
•- Subjects who have history of a massive stroke in cerebrum, brain strem or cerebellum.
•- Subjects who have history of psychiatric disorder.
•- Subjects unable to undergo MRI or PET scanning.
•- Pregnent or reast feeding women.

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