KCT0005428
Recruiting
未知
Building vascular cognitive impairment cohort for development of a dementia risk assessment system and identification of pathophysiologycal interaction between vascular aging and neurodegeneration.
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Gachon University Gil Medical Center
- Enrollment
- 360
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Cognitively Normal (CN)
- •Normal cognition will be defined according to neuropsychological testing, which didn't fall within 1\.5 SD, and Clinical Dementia Rating (CDR) was 0 .
- •\- Mild cognitive impairment (MCI):
- •CDR was 0\.5
- •Subjects were not be clinically diagnosed with dementia according to Diagnostic and Statistical Manual of Mental Disorders, 4th. Edition, Text\-revision (DSM\-IV\-TR) criteria.
- •\- Dementia (AD and SVaD)
- •\- Alzheimer's disease (AD)
- •CDR \= 0\.5
- •subjects were diagnosed with dementia according to DSM\-IV\-TR.
- •subjects were diagnosed with probable AD or possible AD according to the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and Related Disorders Association (NINCDS\-ADRDA) criteria.
Exclusion Criteria
- •\- Subjects who do not meet the inclusion criteria.
- •\- Subjects who have history of any significant neurological disease other than AD or VD , such as traumatic brain injury, Parkinson's disease, Huntington's disease, motor neuron disease, or multiple sclerosis.
- •\- Subjects who have history of brain tumor, normal presure hydrocephalus, encephalitis, or metabolic encephalopathy.
- •\- Subjects who have history of a massive stroke in cerebrum, brain strem or cerebellum.
- •\- Subjects who have history of psychiatric disorder.
- •\- Subjects unable to undergo MRI or PET scanning.
- •\- Pregnent or reast feeding women.
Outcomes
Primary Outcomes
Not specified
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