Water Uptake for Health in Amhara Pilot

Not Applicable

Completed

• Conditions: Trachoma

• Registration Number: NCT02373657
• Lead Sponsor: University of California, San Francisco

Brief Summary

Trachoma is a blinding disease caused by ocular strains of Chlamydia trachomatis. The Carter Center and Proctor Foundation have been jointly conducting trachoma research in the Goncha Siso Enese woreda of Amhara for the past 8 years, through a series of clinical trials. We have found that repeated mass administration of oral azithromycin can greatly reduce the prevalence of trachoma, but mass antibiotics have been unable thus far to eliminate infection. The World Health Organization recommends not only antibiotics for control of trachoma, but an entire SAFE strategy (Surgery for in-turned eyelids, Antibiotics, Facial hygiene promotion, and Environmental improvements such as latrines and water points). Trachoma is more common in villages and households with poor access to water and latrines, so improving the public health infrastructure is thought to be important for limiting transmission of trachoma. However, there is very little evidence to support the efficacy of installing new water points for trachoma. There has been only one previous attempt to study the role of hand dug well installation for trachoma control, and this study, conducted in Niger, found that installing wells was not effective. We now propose a project to improve the public health infrastructure of Goncha Siso Enese woreda by helping with the construction of water points (e.g., hand-dug wells) and providing hygiene education, in order to determine whether improving access to water and hygiene information will be effective for control of trachoma and soil-transmitted helminths.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-04
• Study First Submitted: 2015-02-23
• Study First Submitted QC: 2015-02-26
• Study First Posted: 2015-02-27
• Primary Completion: 2017-05
• Study Completion: 2017-05
• Status Verified: 2021-06
• Last Update Submitted: 2021-06-23
• Last Update Posted: 2021-06-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 4068

Inclusion Criteria

• All residents residing in the state-teams which are randomly selected for this study.

Exclusion Criteria

• Refusal of village chief (for village inclusion), or refusal of parent or guardian (for individual inclusion)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Prevalence of soil transmitted helminths (Ascaris, Trichuris trichiura, and hookworm) (0-5 year olds)	24 months
Prevalence of ocular chlamydia infection (0-5 year olds)	24 months
Nasopharyngeal macrolide resistance (0-5 year olds)	24 months

Secondary Outcome Measures

Name	Time	Method
Clinically active trachoma in children aged 0-5, as determined by the WHO simplified grading system	24 months
Childhood growth (weight controlled for height among children aged 0-5 years at baseline)	24 months
Prevalence of enteric viruses using PCR (0-5 year olds)	24 months
Self report childhood morbidity	24 months

Trial Locations

Locations (1)

The Carter Center; 🇪🇹 Addis Ababa, Ethiopia