icotine salts

Conditions: ot applicable

Registration Number: NL-OMON20501

Lead Sponsor: RIVM

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 84

Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet all of the following criteria:
- Aged 18 to 70 years at the time of inclusion
- Vaping at least more than once per week
- Used to vape e-liquids with nicotine (>1 mg)
- Generally healthy as self-reported
- Owning and using a refillable e-cigarette
- Owning and familiar with using a computer (with webcam and microphone)

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded from participation in this study:
- Women only: pregnant or lactating
- Experiences negative health effects of vaping or smoking
- Asthma or other lung disease

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Perceived liking, nicotine intensity (buzz), harshness/throat hit, pleasantness of throat hit, and willingness to use again (on a 100-unit VAS scale) for nicotine free-base and nicotine salts e-liquids. <br>Puffing intensity (average puff number, puff duration and time between puffs for nicotine free-base and nicotine salts e-liquids.

Secondary Outcome Measures

Name	Time	Method
- Gender, smoking status (dual use), liquid order and used to nicotine salts.<br>- Difference in liking, nicotine intensity (buzz), harshness/throat hit, pleasantness of throat hit over time (after 5 min versus after 10 min).<br>- Correlation coefficients between liking, intensity, harshness/throat hit, pleasantness of throat hit, and nicotine buzz.