A pharmacological trial with Sativex® and gentamicin for optimized pharmacological treatment of older patients with a focus on appetite stimulation and renal risk drugs - CanPA

Copenhagen University Hospital, Amager and Hvidovre, Department of Clinical Research0 个研究点目标入组 69 人开始时间: 2021年7月12日最近更新: 2021年10月8日

适应症

试验速览

暂无简介。

•Admitted to the Department of Emergency Medicine, Hvidovre Hospital
•Can cooperate cognitively
•Risk of malnutrition defined by NRS-2002 score =3
•Low appetite / age-related anorexia measured with SNAQ score =14
•Must be able to read and understand Danish
•Postmenopausal defined as missed periods for at least 12 months before the start of the trial
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) no
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 69

•Regular use of medical cannabis (patient reported)
•Use of medical cannabis within 14 days at baseline (patient reported)
•Recognized or suspected psychotic illness in the subject or his family (medical record and patient report)
•Severe personality disorders (journal)
•Significant psychiatric disorder in addition to mild to moderate depression (journal)
•Allergy to the ingredients of Sativex®, placebo and Hexamycin® (patient reported)
•Terminal diagnosis (journal)
•Cancer disease (journal)
•Liver transplant (journal)
•Chronic eGFR =15 mL / min2 or dialysis treatment (journal)
•Pacemaker (journal)
•Epilepsy (journal)
•Recurrent seizures (journal)
•Severe cardiovascular disease NYHA IV (journal)
•Previous heart attack (journal)
•Uncontrolled hypertension (journal)
•Cardiac arrhythmias (journal)
•Food intolerance to the ingredients in the test meals (patient reported)
•Vegetarian and vegan (patient reported)
•Unwilling to avoid driving for up to 72 hours after administration of Sativex® (patient-reported)
•Unwilling to avoid alcohol 24 hours up to the trial days (patient reported)
•Patients with ascites (medical record)
•Patients with significant edema on the days of the trial (medical record / visual inspection)

发起方

Copenhagen University Hospital, Amager and Hvidovre, Department of Clinical Research