Association Between Fractional Exhaled Nitric Oxide and Asthma Control
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 62
- 试验地点
- 1
- 主要终点
- fractional exhaled nitric oxide level
研究概览
简要总结
The purpose of this study is to determine mean or median of fractional exhaled nitric oxide (FeNO) in Thai atopic asthmatic patients that divided into subgroups due to level of asthma control according to the global initiative for asthma guideline.
详细描述
From many previous studies, fractional exhaled nitric oxide (FeNO) has many benefits such as non-invasive, easily to perform, less time consume, has direct association with severity of inflammation of bronchial trees and sputum eosinophils, has benefit for diagnosis and monitoring the treatment in asthmatic patients.
In Thailand, this field of study is less extend, especially in children population. We hypothesized that in uncontrolled or partly controlled group may have high level of fractional exhaled nitric oxide (FeNO) than controlled group.
It is therefore desirable to examine the association between fractional exhaled nitric oxide (FeNO) and level of asthma control among atopic asthmatic Thai children and will be the main objective of this research.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 7 Years 至 60 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •clinical diagnosis of atopic bronchial asthma
- •follow up in clinic of allergy and clinical immunology, Siriraj hospital
排除标准
- •smoker or past history of smoking
- •has chronic disease eg. HIV infection, pulmonary hypertension, systemic lupus erythematosus, liver cirrhosis, gastroesophageal reflux, COPD, bronchiectasis
- •drink ethanol within 48 hours before enrollment
- •history of upper or lower respiratory tract infection within 6 weeks before enrollment
- •drink caffeine within day before enrollment
- •during pregnancy
- •history of systemic steroid use within 8 weeks before enrollment
结局指标
主要结局
fractional exhaled nitric oxide level
时间窗: 10 minutes (average time), on the day of enrollment
次要结局
- scores of asthma control test: ACT(5 minutes (average time), on the day of enrollment)
研究者
Nualanong Visitsunthorn
Professor
Mahidol University