Proteases in Prostate Cancer Bone Metastasis
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Anemia
- Sponsor
- Barbara Ann Karmanos Cancer Institute
- Enrollment
- 31
- Locations
- 1
- Primary Endpoint
- Expression and activity of proteases and related molecules
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
RATIONALE: Collecting and storing samples of bone marrow and tissue from patients to test in the laboratory may help the study of cancer.
PURPOSE: This laboratory study is comparing proteases (enzymes that break down protein) in patients with prostate cancer that has spread to the bone with patients who do not have cancer that has spread to the bone.
Detailed Description
OBJECTIVES: * Examine the roles of proteases and protease-associated molecules in bone metastases in patients with metastatic prostate cancer. OUTLINE: Patients undergo bone marrow aspiration and core bone biopsies. Tissues are analyzed by immunohistochemistry methods, in situ hybridization assays, gelatin zymography and/or Western blot analysis, and gene profiling analysis in order to visualize and quantitate protease or protease-related levels. PROJECTED ACCRUAL: A total of 50 patients will be accrued for this study.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Expression and activity of proteases and related molecules