Percutaneous Revascularization in Infarction With Late Presentation and Absence of Viability: Effects on Left Ventricular Remodeling and Contractility
Overview
- Phase
- N/A
- Intervention
- Optimized Medical Treatment (OMT)
- Conditions
- STEMI - ST Elevation Myocardial Infarction
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
- Enrollment
- 70
- Locations
- 1
- Primary Endpoint
- Reverse myocardial remodeling after late recanalization in patients without viability
- Last Updated
- 4 years ago
Overview
Brief Summary
The purpose of this study is to evaluate whether late recanalization in patients with ST elevation myocardial infarction (STEMI) without Viability on Cardiovascular Magnetic Resonance Image (MRI) can reduce the reverse remodeling through the reduction of the End Systolic Volume (ESV) at 6 months.
Detailed Description
The purpose of this study is to evaluate whether late recanalization in patients with ST elevation myocardial infarction (STEMI) without Viability on Cardiovascular Magnetic Resonance can reduce the reverse remodeling through the reduction of the End Systolic Volume (ESV) at 6 months and through the improvement in segmental contractility of infarcted related artery at MRI.
Investigators
Barbara Porto Valente
Cardiology Physician
Instituto Dante Pazzanese de Cardiologia
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
Optimized Medical Treatment (OMT)
The patient considered non-viable by MRI and randomized to Optimized Medical Treatment (OMT) will be treated according to Optimized Medical Treatment guidelines for Coronary Artery Disease (CAD)
Intervention: Optimized Medical Treatment (OMT)
Angioplasty (PCI) and Optimized Medical Treatment (OMT)
The patient considered non-viable and randomized to Coronary Angioplasty will be treated with drug-eluting stent (PCI) and Optimized Medical Treatment (OMT)
Intervention: Optimized Medical Treatment (OMT)
Angioplasty (PCI) and Optimized Medical Treatment (OMT)
The patient considered non-viable and randomized to Coronary Angioplasty will be treated with drug-eluting stent (PCI) and Optimized Medical Treatment (OMT)
Intervention: Drug Eluting Stent (DES) Coronary Angioplasty
Outcomes
Primary Outcomes
Reverse myocardial remodeling after late recanalization in patients without viability
Time Frame: 6 months
Evaluate reverse remodeling after late recanalization in patients without viability measuring End Systolic Volume (ESV) by MRI
Secondary Outcomes
- Assessement of Myocardial contractility(6 months)
- Unplanned revascularization (Ischemia Driven and Not Ischemia Driven)(6 months)
- Stroke Event(6 months)
- Assessement of Left Ventricle Ejection Fraction (LVEF)(6 months)
- Cardiovascular Death(6 months)
- Evaluate Quality of Life(6 months)
- Acute MI Event(6 months)
- Cardiovascular-Related Hospitalization(6 months)