Effects of Exercise Training on Quadriceps Gene Expression in COPD-patients in Comparison to Alpha-1-Antitrypsin-deficiency-patients
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 20
- Locations
- 2
- Primary Endpoint
- aerobic and anaerobic enzymes
Study Overview
Brief Summary
Chronic Obstructive Pulmonary Disease (COPD)-patients (caused by smoking-level) and Alpha-1-Antitrypsin-deficiency patients showed different developments during rehabilitation in regard to improvement of 6-minute-walking distance. The aim of this study is to investigate differences between training adaptations in COPD-patients and Alpha-1-deficiency patients. Both groups take part in a standardized multimodal 3-week-rehabilitation with strength and endurance training. In addition to conventional diagnostic procedures, muscle biopsies from the M. vastus lateralis will be conducted before and after rehabilitation program followed by biochemical, histochemical and immunohistochemical analysis of the probes.
Study Design
- Study Type
- Interventional
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 40 Years to 75 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Alpha-1-Antitrypsine-deficiency, phenotype: ZZ
- •FEV1%pred. <50
Exclusion Criteria
- •acute exacerbation
- •exacerbation in the last 4 weeks
Outcomes
Primary Outcomes
aerobic and anaerobic enzymes
Time Frame: day 2 and 23
changes in quantity of enzymes from baseline to day 23
Secondary Outcomes
- maximal exercise capacity in incremental cycling test(day 2 and 23)
- 6-minute-walking distance(day 3 and 24)
Investigators
Klaus Kenn
Head physician (department of pneumology)
Schön Klinik Berchtesgadener Land