Effects of Exercise Training on Quadriceps Gene Expression in COPD-patients in Comparison to Alpha-1-Antitrypsin-deficiency-patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- aerobic and anaerobic enzymes
研究概览
简要总结
Chronic Obstructive Pulmonary Disease (COPD)-patients (caused by smoking-level) and Alpha-1-Antitrypsin-deficiency patients showed different developments during rehabilitation in regard to improvement of 6-minute-walking distance. The aim of this study is to investigate differences between training adaptations in COPD-patients and Alpha-1-deficiency patients. Both groups take part in a standardized multimodal 3-week-rehabilitation with strength and endurance training. In addition to conventional diagnostic procedures, muscle biopsies from the M. vastus lateralis will be conducted before and after rehabilitation program followed by biochemical, histochemical and immunohistochemical analysis of the probes.
研究设计
- 研究类型
- Interventional
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Alpha-1-Antitrypsine-deficiency, phenotype: ZZ
- •FEV1%pred. <50
排除标准
- •acute exacerbation
- •exacerbation in the last 4 weeks
研究组 & 干预措施
exercise training
干预措施: exercise training (Procedure)
结局指标
主要结局
aerobic and anaerobic enzymes
时间窗: day 2 and 23
changes in quantity of enzymes from baseline to day 23
次要结局
- maximal exercise capacity in incremental cycling test(day 2 and 23)
- 6-minute-walking distance(day 3 and 24)
研究者
Klaus Kenn
Head physician (department of pneumology)
Schön Klinik Berchtesgadener Land