Acute Neuroimmune Effects of Alcohol Using Free Water Imaging
Not Applicable
Completed
- Conditions
- Alcohol Drinking
- Registration Number
- NCT03370783
- Lead Sponsor
- Brown University
- Brief Summary
This study examines the effects of moderate alcohol intake on the brain, the immune system, and cognition.
- Detailed Description
The study involves a within-subjects, pre/post design to assess the effects of a moderate dose of alcohol on immune biomarkers, neurobiological measures, and cognitive functioning. The study recruits healthy adults (ages 21-45) from the community to complete the experimental protocol. Participants complete magnetic resonance imaging scans, blood sample collection, and cognitive testing in the context of alcohol consumption.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 25
Inclusion Criteria
- Ages 21-45 years
- Able to speak and read English at least at 8th grade level
- Moderate self-reported alcohol use in the past year
- Body mass index in normal to overweight range
- Right-handed
Exclusion Criteria
- History of heavy drinking
- Currently seeking alcohol or drug treatment
- Chronic disease requiring use of medication
- Recent antibiotic or probiotic use
- Chronic daily use of NSAIDs
- Chronic GI disorder
- Use of illicit drugs
- Major psychiatric disorder or suicidality
- Fainting, weakness, infection, excessive bruising, or distress resulting from standard blood draw
- Safety contraindication for MRI scan
- Inability to abstain from use of tobacco products prior to or during study
- Inability to abstain from use of cannabis prior to or during study
- Pregnant, nursing, or may become pregnant
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Immune biomarkers 1-3 hours after alcohol intake
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Brown University
🇺🇸Providence, Rhode Island, United States