The influence of dance training and strenght / endurance training on cognitive functions and the plasticity of the brain in senior citizens with an increased vascular risk

Not Applicable

Conditions: I67.3
Progressive vascular leukoencephalopathy

Registration Number: DRKS00011056

Lead Sponsor: niversitätsMedizin Mannheim

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting withdrawn before recruiting started

Sex: All

Target Recruitment: 90

Inclusion Criteria

1. age = 60 years
2. retired (working < 10 hours / week)
3. able to consent
4. no regular physical activity before study inclusion
5. willingness and availability to participate in training during the 12-month period regularly
6. German as native language
7. evidence of a relevant small vessel disease (Fazekas score 1 or higher)

Exclusion Criteria

1. contraindication against magnetic resonance imaging (cardiac pace maker, metal implants, claustrophobia)
2. history of a neurological disease with functional impairment
3. history of a psychiatric disease with functional impairment
4. diagnosis of a dementia or a cognitive impairment relevant for daily life
5. malignancy, life expectancy < 12 months
6. clinically significant cardiac disease, e.g. insufficiency NYHA III / IV, cardiac infarction within six weeks of inclusion, unsuited for sports
7. clinically significant pulmonary disease, e.g. COPD III / IV
8. planned surgical procedure during 12 month study intervention
9. visual or hearing impairment, interfering with neuropsychological testing or fMRI
10. intake of neuroleptics or anti-dementia drugs
11. MoCA = 20
12. MRI evidence of an intracranial hemorrhage, a cortical infarction, a space-occupying lesion, white matter lesion mimics

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Course of performance in dual tasks split attention: 1. hand motor speed and visuomotor differentiation (grooved pegboard) / serial subtraction, 2. gait (computer-assisted gait analysis) / counting months backward, 3. gait (computer-assisted gait analysis) / balance (carrying a tablet with a glass filled with water). Analysis: MANOVA, time points: before intervention, after 6 months, after 12 months.

Secondary Outcome Measures