Brain function in macro- and micro-networks - an ECoG/stereo-EEG and fMRI approach
- Conditions
- primary objective 2: locked-in syndroom, primary objective 3: epilepsieNA
- Registration Number
- NL-OMON56331
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 117
- Epilepsy patient (m/f) scheduled for implantation with ECoG grids (for ECoG
population) or stereo-EEG electrodes (for stereo-EEG population)
- 18 years or older
There are no exclusion criteria for the current study. If a patient fulfils the
inclusion criteria and gives informed consent, he/she can be included in the
study. If a subject does not qualify for 3T and/or 7T fMRI (because of e.g.
unremovable metals in the body), or is not willing to perform one or both of
these scans, he / she will be asked to contribute to the ECoG or stereo-EEG
part of the study. If a patient has already performed a clinical fMRI scan, or
when clinical fMRI tasks are combined with research fMRI tasks in the same
session, we will evaluate whether it is possible to use the data of the
clinical scan/tasks for this research, to avoid having to perform a new fMRI
scan, or a repetition of the same tasks, to minimize burden. Whether or not
this is possible will depend on, among others, the task battery performed
clinically.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The end-points are described per primary objective:<br /><br>- Establishment and modeling (quantification) of the relationship between<br /><br>hemodynamic signals measured with fMRI and underlying neuronal activation<br /><br>patterns<br /><br>- The ability of patients to achieve high-dimensional BCI control<br /><br>- The correspondence between fMRI and ECS and between ECoG/stereo-EEG and ECS<br /><br>- Function-selective measures of network dynamics, i.e. connectivity, causality<br /><br>and spatiotemporal patterns</p><br>
- Secondary Outcome Measures
Name Time Method <p>NA</p><br>