Evaluation of the Presence of Enthesitis in Patients With Acne Vulgaris

• Conditions: Enthesitis; Acne Vulgaris; Ultrasonography
• Interventions: Diagnostic Test: ultrasonography

• Registration Number: NCT04224597
• Lead Sponsor: Erol Olcok Corum Training and Research Hospital

Brief Summary

Acne vulgaris is an inflammatory disease of the pilosebaceous unit, affecting about 85% of the young population. In the studies p. acne is a potent stimulator of the release of IFN-gamma (IFN-)) and IL-17 from CD4 + T cells, and the presence of IL-17 + cells in the perifollicular infiltrate has been shown in biopsies of inflammatory acne lesions. Therefore, acne is thought to be a Th17-related disease (1).

This study was aimed to evaluate the presence of enthesitis in patients with acne vulgaris.

Detailed Description

Patients with acne vulgaris and healthy controls aged between 18-25 who admitted to Hitit University Erol Olcok Education and Research Hostpital Dermatology policlinic will be icluded. Patients with rheumatic, neurological diseases, history of trauma and previous fractures will be excluded from the study. After all the participants were evaluated by the dermatologist and demographic data will be recorded, the participants will be examined by the physical medicine and rehabilitation specialist and the short form-36 (sf-36), hospital anxiety and depression scale will be completed. Bilateral lower extremity tendon thicknesses and the presence of erosion, bursitis, etc. will be evaluated according to the criteria of Guess (Glasgow Ultrasound Enthesitis Scoring System) and Guess score will be determined for all participants. A total of 48 participants, 24 patients with acne vulgaris and 24 healthy controls, will be included in the study (2).

Study Timeline

• Status Verified: 2020-01
• Study First Submitted: 2020-01-08
• Study First Submitted QC: 2020-01-08
• Study First Posted: 2020-01-13
• Last Update Submitted: 2020-01-23
• Last Update Posted: 2020-01-27
• Study Start: 2020-02-01
• Primary Completion: 2020-04-01
• Study Completion: 2020-04-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 48

Inclusion Criteria

Not provided

Exclusion Criteria

• Participants with rheumatic and neurologic disease, history of trauma ,

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with acne vulgaris	ultrasonography	patients with acne vulgaris aged between 18-25 year
Healthy controls	ultrasonography	healthy controls aged between 18-25 year

Primary Outcome Measures

Name	Time	Method
patellar tendon thicknesses of patients with acne vulgaris and healthy controls	3 months
Ashilles tendon thicknesses of patients with acne vulgaris and healthy controls	3 months

Trial Locations

Locations (1)

Dilek Eker Büyükşireci; 🇹🇷 Çorum, Central Anatolia, Turkey