Comparing the Use of Dienogest and Combined Oral Contraceptive Pills (Microgynon) to Reduce the Risk of Recurrence of Endometriotic Cyst After Conservative Surgery
- Registration Number
- NCT02385448
- Lead Sponsor
- The University of Hong Kong
- Brief Summary
The purpose of the study is to compare the recurrence of endometriotic cyst in patients taking Dienogest or Microgynon after conservative surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 144
Inclusion Criteria
- Good general health
- Older than the age of legal consent (i.e. 18 years old)
- Sonographic diagnosis of ovarian endometrioma with diameter at least 4cm on 2 separate scans at least 6 weeks apart
- No contraindication to use of progesterone or combined oral contraceptive pills
- Not attempting to conceive either at the time of study entry or for at least 2 years after surgery
- Willing and able to participate after the study has been explained
Exclusion Criteria
- Operative findings not suggestive of endometriotic cyst
- Contraindications to progestogens or oral contraceptive pills
- Unwillingness to tolerate menstrual irregularity
- Planning pregnancy within 2 years of study
- Cannot understand English, Cantonese or Putonghua
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Dienogest Dienogest - Combined oral contraceptive pills Microgynon -
- Primary Outcome Measures
Name Time Method Recurrence of ovarian endometrioma 2 years Size of recurrent endometrioma on sonography (mean diameter in centimeters)
- Secondary Outcome Measures
Name Time Method Side effects 2 years Days of irregular bleeding
Need for additional analgesics 2 years Types of analgesics used
Symptoms of endometriosis 2 years Pain by visual analog score
Trial Locations
- Locations (1)
Queen Mary Hospital
ðŸ‡ðŸ‡°Hong Kong, Hong Kong