Genetical Background of Non-alcoholic Fatty Liver Disease (NAFLD) in Diabetes Mellitus and in Chronic Kidney Disease
试验速览
- 阶段
- 不适用
- 入组人数
- 600
- 试验地点
- 1
- 主要终点
- Association of genetical factors with NFS and HSI
研究概览
简要总结
The present study investigates relationship between non-alcoholic fatty liver disease and its risk factors, such as genetic background and diseases, such as chronic kidney disease and diabetes mellitus.
详细描述
Non-alcoholic fatty liver disease (NAFLD) is a multisystemic disease, also affecting extrahepatic organs (1,2,6). According to former data, not only the prevalence of chronic hepatic disease, chronic cardiovascular diseases, but also the prevalence of chronic kidney disease (CKD) is higher in NAFLD (4,7). A strong association has been shown between diabetes mellitus (DM) and NAFLD as well (3,5,10).
Many genetical factors have been studied in the background of NAFLD. Many studies have proved the effect of patatin-like phospholipase domain-containing protein 3 gene (PNPLA3) (8,9). Effect of numerous genetical polymorphisms has been suggested behind oxidative stress responsible for NAFLD (8).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •CKD (renal replacement therapy non excluded)
排除标准
- •alcohol abuse
结局指标
主要结局
Association of genetical factors with NFS and HSI
时间窗: 2 years
The association of hepatic steatosis with genetic factors will be assessed. In case of patatin-like phospholipase domain-containing protein 3 gene (PNPLA3) : rs738409, rs2281135, rs2294918 single nuclear polimorfism (SNP) will be examined
Association of NFS (NAFLD fibrosis score) and HSI (hepatic steatosis index) with underlying conditions
时间窗: 2 years
The association of hepatic steatosis with chronic kidney disease, diabetes mellitus and the the persence of these two will be assessed
次要结局
- Association of glucose metabolism parameters with hepaic steatosis indices(2 years)
- The relationship between blood count, sedimentation and inflammation with hepatic setatosis indices(2 years)
- Association of liver function and hepatic setatosis indices(2 years)
- Assotion of serum proteins with hepatic setatosis indices(2 years)
- Association of iron metabolism parameters with hepatic setatosis indices(2 years)
- Association of pathological tyrosine isoforms with hepatic setatosis indices(2 years)
- Association of hepatic steatosis with renal function(2 years)
- Association of serum lipid profile and hepatic setatosis indices(2 years)