Influence of Tidal Volume on Postoperative Pulmonary Function
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pulmonary Function
- Sponsor
- Heinrich-Heine University, Duesseldorf
- Enrollment
- 101
- Locations
- 1
- Primary Endpoint
- Lung function as assessed by spirometry
- Status
- Completed
- Last Updated
- 15 years ago
Overview
Brief Summary
Lung function impairment is common after abdominal surgery. Few preventive strategies exist against postoperative lung function impairment. A new potential preventive strategy against postoperative lung function impairment comes from research on critically ill patients with severe respiratory failure. In this field research has long focused on influence of breathing volume (= tidal volume) during mechanical ventilation on outcome. It has been shown, that low tidal volumes improve patients outcomes as compared to (conventional) high tidal volumes. Therefore, we propose a patient and investigator blinded randomised trial to test the hypotheses that intraoperative mechanical ventilation with low tidal volumes as compared to high tidal volumes reduces postoperative lung function impairment in high risk patients.
Investigators
Eligibility Criteria
Inclusion Criteria
- •written informed consent
- •age ≥ 50 years and ASA classification ≥ II
- •elective upper abdominal surgery of at least 3 hours duration
- •general anaesthesia plus epidural anaesthesia.
Exclusion Criteria
- •\< 18 years of age
- •impaired mental state
- •unwillingness to participate
- •pregnancy
- •duration of surgery \< 3 hours
- •ASA physical status ≥ IV
- •increased intracranial pressure
- •neuromuscular disease that impairs spontaneous breathing
Outcomes
Primary Outcomes
Lung function as assessed by spirometry
Time Frame: 1 year
Secondary Outcomes
- postoperative chest x-rays(1 year)
- time till mobilisation(1 year)
- time till hospital discharge(1 year)
- postoperative organ dysfunction(1 year)
- lung function as assessed by blood gas analysis(1 year)