NCT00530478Unknown不适用
Effect of Donepezil on the Reorganization of Cognitive Neural Network in Patients With Post-Stroke Cognitive Impairment
适应症
相关药物
试验速览
- 阶段
- 不适用
- 试验地点
- 1
研究概览
简要总结
The purpose of this study is to demonstrate the efficacy and safety of donepezil on the recovery of cognitive function in patients with stroke and to delineate the neurophysiologic mechanisms of the therapeutic effect of donepezil on the recovery of cognitive network using functional neuroimaging technique.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- None
入排标准
- 年龄范围
- 16 Years 至 80 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Ischemic stroke in the territory of right or left middle cerebral artery
- •Post-onset duration of the recent-onset stroke is over 3 months
- •Cognitive deficit ranged from 10 to 26 by minimal mental status examination (MMSE) score
- •Disturbance in activities of daily living (ADL) ranged 0.5 ~ 2.0 by clinical dementia rating (CDR) scale
排除标准
- •Severe internal carotid artery stenosis on the lesion side
- •Cardiac pacemaker or intracranial metal insertion
- •Post-stroke seizure disorder or any evidence of epileptic spikes on electroencephalography (EEG)
研究者
研究点 (1)
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