Farmacokinetiek van ropivacaïne met en zonder adrenaline bij hoge doseringen voor n. femoralis en ischiadicus blok bij orthopedische chirurgie van de onderste extremiteit.
Completed
- Conditions
- combined femoral and sciatic nerve block for lower extremity orthopedic surgery
- Registration Number
- NL-OMON21564
- Lead Sponsor
- Sint Maartenskliniek Nijmegen, The Netherlands
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 12
Inclusion Criteria
1. Patients over 18 years, under 60 years of age;
2. Body Weight over 70 kg;
Exclusion Criteria
1. Contra-indications for regional anesthesia (infection at the injection site, coagulopathy);
2. Known hypersensitivity to amide-type local anesthetics;
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Mean unbound and bound peak plasma concentration (Cmax) of ropivacaine with and without epinephrine;<br /><br>2. Mean time to unbound and bound peak plasma concentration (Tmax) of ropivacaine with and without epinephrine;<br /><br>3. Range of duration (width) of Cmax¬ after single shot combined femoral and sciatic nerve block with and without epinephrine;<br /><br>4. Range of apparent half-life of ropivacaine with and without epinephrine in combined femoral and sciatic nerve block (T½);<br /><br>5. Efficacy of the sensory blockade with and without epinephrine;<br /><br>6. Duration of the sensory blockade with and without epinephrine.
- Secondary Outcome Measures
Name Time Method