TCTR20210403003尚未招募4 期
Effect after Switching from Efavirenz to Rilpivirine on Liver Steatosis Among People Living with HIV with Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial
Thai AIDs Society0 个研究点目标入组 54 人开始时间: 2021年4月3日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 54
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 80 Years（—）
- 性别
- All
入选标准
- •1. HIV-1 infected patient
- •2. Age >= 18-year-old
- •3. Efavirenz was given in combination with either Tenofovir or Abacavir, and either Emtricitabine or Lamivudine for more than 24 weeks.
- •4. HIV-viral load < 40 copies/mL for more than 24 weeks.
- •5. Hepatic steatosis when measured by Controlled attenuation parameter >= 248 dB / m.
- •6. History of drinking less than 30 grams of alcohol per day in men and less than 20 grams per day in women
排除标准
- •1. Pregnant patients
- •2. History of virologic failure or virologic resistance
- •3. History of opportunistic infections in the past 24 weeks
- •4. Patients with contraindications to rilpivirine, for example receiving all proton pump inhibitors.
- •5. Infected with hepatitis B virus or hepatitis C virus
- •6. BMI more than 30 Kg/m2
- •7. Patients using drugs corticosteroid, methotrexate, amiodarone, valproate
- •8. Patients diagnosed with autoimmune hepatitis, hemochromatosis, Wilson's disease
研究者
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