The Effect of Different Ketone Supplements on Blood Beta-hydroxybutyrate (β-OHB) and Blood Glucose in Healthy Individuals
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- Blood Beta-hydroxybutyrate
研究概览
简要总结
Ketone bodies are a fuel source and signaling molecule that are produced by your body during prolonged fasting or if you consistently eat at low-carbohydrate diet. Blood ketones can be used as a source of energy during fasting and are used by your brain as an alternative source of fuel to glucose. Previous studies have found that ketones, when consumed in form of a supplement drink, can increase blood ketone levels and lower blood glucose, the amount of sugar in your blood. This is of potential interest for individuals with high blood sugar, such as people living with type 2 diabetes. However, there are different types of ketone supplements that differ in how they are metabolized in the body. Little is known about how these supplements affect blood ketone and blood glucose levels. The main objective of this study is to determine the effect of three different ketone supplements on blood ketones and blood glucose. The results of this pilot study will be used to guide future research for larger and more extensive studies on ketone supplements.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •over the age of 18;
- •able to fast overnight
排除标准
- •being a competitive endurance athlete;
- •following a ketogenic diet, low-calorie diet, periodic fasting regimen, or regularly consuming ketogenic supplements;
- •being unable to travel to and from the university;
- •being unable to follow the diet instructions;
- •being pregnant or planning to become pregnant during the study;
- •having been diagnosed with a chronic disorder of glucose or fat metabolism, including type 2 diabetes, chronic pancreatitis, or gallbladder disease;
- •being unable to read or communicate in English
结局指标
主要结局
Blood Beta-hydroxybutyrate
时间窗: 240 minutes (assessed at baseline and 15, 30, 60, 90, 120, 180, 240 minutes post-supplementation)
Are under the curve (AUC) across 240 minutes after supplement consumption (assessed at baseline and 15, 30, 60, 90, 120, 180, and 240 post-supplementation)
次要结局
- Hunger & Fullness(240 minutes post-supplementation)
- Blood Pressure(240 minutes (assessed at baseline and 15, 30, 60, 90, 120, 180, 240 minutes post-supplementation))
- Supplement Acceptability & Taste(240 minutes post-supplementation)
- Gastrointestinal Discomfort(60 minutes post-supplementation)
- Blood Glucose(240 minutes (assessed at baseline and 15, 30, 60, 90, 120, 180, 240 minutes post-supplementation))
- Heart Rate(240 minutes (assessed at baseline and 15, 30, 60, 90, 120, 180, 240 minutes post-supplementation))
研究者
Jonathan Little
Dr. Jonathan Little, Associate Professor
University of British Columbia