Kinetics of IroN in Donors

Completed

• Conditions: fysiologisch herstel na bloeddonatie in gezonde mannen; Iron status after blood donation; erythropoiese

• Registration Number: NL-OMON37151
• Lead Sponsor: Sanquin Bloedbank

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

Male, 2 or less blood donations or 10 or more blood donations, BMI between 20 and 27, length at least 175 cm, age between 30 and 50, ALT and CRP normal at start

Exclusion Criteria

vegetarian, blood type O neg, HFE mutation (homozygote C282Y or compound heterozygote C282Y/H63D genotype)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Hb and red cell and reticulocyte indices (MCV, MCH, RDW, Ret Hb), serum iron<br /><br>parameters (iron, ferritin, transferrin, transferrin saturation, serum<br /><br>transferrin receptor (sTfR), zinc protoporphyrin (ZPP), hepcidin) and<br /><br>erythropoiesis marker (EPO).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Blood volume, number of previous donations, donation frequency</p><br>