Venoarterial PCO2 Difference /Arteriovenous O2 Content Difference Ratio as Goal of Early Septic Shock Therapy

Not Applicable

• Conditions: Septic Shock

• Registration Number: NCT01877798
• Lead Sponsor: Peking Union Medical College Hospital

Brief Summary

Reducing tissue hypoxia is the ultimate goal of severe sepsis and septic shock therapy.Venoarterial PCO2 difference /arteriovenous O2 content difference ratio (△PCO2/Ca-vO2) is considered to be a good indicator of global anaerobic metabolism.The purpose of this study was to compare the efficacy of △PCO2/Ca-vO2 and central venous oxygen saturation (ScvO2) in the treatment of severe sepsis and septic shock.

Detailed Description

Not available

Study Timeline

• Status Verified: 2013-06
• Study Start: 2013-06
• Study First Submitted: 2013-06-12
• Study First Submitted QC: 2013-06-13
• Last Update Submitted: 2013-06-13
• Study First Posted: 2013-06-14
• Last Update Posted: 2013-06-14
• Primary Completion: 2016-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• severe sepsis and septic shock patients

Exclusion Criteria

• <18 years old
• pregnant and breast-feed woman
• AMI
• cerebral hemorrhage
• contraindication for central venous catheter or arterial catheter;
• brainstem death

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
mortality	30 days

Trial Locations

Locations (1)

Peking Union Medical College Hospital critical care medicine; 🇨🇳 Beijing, China