Venoarterial PCO2 Difference /Arteriovenous O2 Content Difference Ratio as Goal of Early Septic Shock Therapy

Not Applicable

• Conditions: Septic Shock
• Interventions: Procedure: volume resuscitation, vasoactive drug

• Registration Number: NCT01877798
• Lead Sponsor: Peking Union Medical College Hospital

Brief Summary

Reducing tissue hypoxia is the ultimate goal of severe sepsis and septic shock therapy.Venoarterial PCO2 difference /arteriovenous O2 content difference ratio (△PCO2/Ca-vO2) is considered to be a good indicator of global anaerobic metabolism.The purpose of this study was to compare the efficacy of △PCO2/Ca-vO2 and central venous oxygen saturation (ScvO2) in the treatment of severe sepsis and septic shock.

Detailed Description

Not available

Study Timeline

• Status Verified: 2013-06
• Study Start: 2013-06
• Study First Submitted: 2013-06-12
• Study First Submitted QC: 2013-06-13
• Last Update Submitted: 2013-06-13
• Study First Posted: 2013-06-14
• Last Update Posted: 2013-06-14
• Primary Completion: 2016-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• severe sepsis and septic shock patients

Exclusion Criteria

• <18 years old
• pregnant and breast-feed woman
• AMI
• cerebral hemorrhage
• contraindication for central venous catheter or arterial catheter;
• brainstem death

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
△PCO2/Ca-vO2	volume resuscitation, vasoactive drug	△PCO2/Ca-vO2 directed group
ScvO2	volume resuscitation, vasoactive drug	ScvO2 directed group

Primary Outcome Measures

Name	Time	Method
mortality	30 days

Trial Locations

Locations (1)

Peking Union Medical College Hospital critical care medicine; 🇨🇳 Beijing, China