Neonatal Precursors of Neurodevelopment
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Premature Birth
- Sponsor
- University Hospital, Caen
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- Frontal-parietal structural connectivity
- Status
- Recruiting
- Last Updated
- 4 years ago
Overview
Brief Summary
The NEOPRENE project proposes to examine processes that are among the earliest precursors of cognitive functions and assess 1) the relationship between neonatal cognitive precursors and cortical structure, structural connectivity and functional connectivity at birth and 2) the relationship between neonatal cognitive precursors and neurodevelopment.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Preterm newborn (born \< 34 weeks + 6days)
Exclusion Criteria
- •Brain injury
- •Respiratory assistance on measurement day
- •Infection on measurement day
- •Sedation on measurement day
- •Parents \< 18 years old or unable to give informed consent
Outcomes
Primary Outcomes
Frontal-parietal structural connectivity
Time Frame: 35 weeks GA
Tractography using Diffusion tensor Imaging in magnetic resonance imaging
Frontal-parietal functional connectivity
Time Frame: 35 weeks GA
Synchronization at rest using blood-oxygen level dependent signal in magnetic resonance imaging
Quality of cognitive development
Time Frame: 2 years old
Qualitative composite assessment using clinical interview, routine pediatric screening and questionnaires (full sensory profile, preschooler Behavior Rating Inventory of Executive Function)
Electroencephalography evoked response amplitude
Time Frame: 35 weeks of gestational age
Electrical field potential changes in the parietal and frontal cortices
Near infrared spectroscopy evoked response amplitude
Time Frame: 35 weeks of gestational age
Oxygenated hemoglobin concentration changes in the somatosensory cortex
Grey matter volume in the somatosensory cortex
Time Frame: 35 weeks GA
Thickness measured on T2 images in magnetic resonance imaging