NCT00162383Unknown不适用
Phenotypic and Genotypic Evaluation of Cytochrome P450 Isoforms in Populations of Different Ethnic Composition
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 入组人数
- 1,200
- 试验地点
- 1
- 主要终点
- Phenotypic measurements of various P450 and non-P450 enzymes involved in drug metabolism.
研究概览
简要总结
The ability to metabolize drugs varies greatly among individuals. Major fraction of this variability lies in genetic polymorphisms of genes encoding for enzymes responsible for both phase I and phase II reactions.
The purpose of this study ws to evaluate the phenotypic activity and the frequency of genetic polymorphisms in different phase II and phase I enzymes among various populations residing in Israel.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age range 20-50
- •Absence of significant disease state
排除标准
- •The presence of significant disease states
- •The regular use of drugs (including birth control pills)
研究组 & 干预措施
Cocktail
Experimental
干预措施: Caffeine (Drug)
Cocktail
Experimental
干预措施: Debrisoquine (Drug)
Cocktail
Experimental
干预措施: Mephenytoin (Drug)
Cocktail
Experimental
干预措施: Dapsone (Drug)
结局指标
主要结局
Phenotypic measurements of various P450 and non-P450 enzymes involved in drug metabolism.
时间窗: 24 hours
Frequency of genetic polymorphisms in these enzymes among different Israeli populations.
时间窗: 24 hours
次要结局
未报告次要终点
研究者
研究点 (1)
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