Using MRI for a Non-invasive Evaluation of Portal Pressure
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Correlation between portosystemic pressure gradient measured by catheterization of the hepatic veins transjugular and azygos flow measured by MRI.
研究概览
简要总结
The objective of this research is to study the correlation between the portosystemic pressure gradient and azygos blood flow measured by MRI.
详细描述
All patients will benefit from:
- Pressure gradient measurement portosystemic
- MRI measurement of azygos flow, aortic, portals, spleen and lower cellar
- Liver biopsy
- Laboratory tests
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Suspicion of chronic liver disease
- •Indication to perform a liver biopsy transjugular
- •Patient able to consent
排除标准
- •contraindication to MRI:
- •Holders of a pacemaker or a defibrillator, an implanted material activated by electrical, magnetic or mechanical
- •Holders of hemostatic clips intracerebral aneurysms or carotid arteries, bearing orthopedic implants
- •claustrophobic
- •Severe hepatic encephalopathy
- •Inability to MRI in the week surrounding the first jugular
研究组 & 干预措施
Intervention
The measurement of portosystemic pressure gradient will be performed before liver biopsy.
Then liver biopsy is performed. The MRI was performed on the day of biopsy or within one week around the completion of the biopsy.
The MRI machine used is the Siemens 3T.
干预措施: Intervention (Procedure)
结局指标
主要结局
Correlation between portosystemic pressure gradient measured by catheterization of the hepatic veins transjugular and azygos flow measured by MRI.
时间窗: 1 week
MRI and catheterization will be performed the same week. For the azygos blood flow (by MRI), measures will be repeated 5 times. Speed of extraction and the rate on the post processing console will be made with a double reading. For the measurement of portal pressure by catheterization, will be performed measurements of occluded hepatic vein pressure and free hepatic vein. They will be repeated 3 times each. These measures will be carried out to calculate the portosystemic pressure gradient. The flow rate and gradient measurements will be performed blindly to the other.
次要结局
- Correlation between portosystemic pressure gradient measured by catheterization of the hepatic veins transjugular and throughput inferior vena measured by MRI.(1 week)
- Correlation between portosystemic pressure gradient measured by catheterization of the hepatic veins transjugular and aortic flow measured by MRI.(1 week)