Seminal Plasma Galectin-3 levels in patients with male factor infertility undergoing assisted reproductive techniques (ART) and relation of Galectin-3 levels with sperm parameters and cycle outcomes

Not Applicable

Completed

• Conditions: Infertility; Reproductive Health and Childbirth - Fertility including in vitro fertilisation

• Registration Number: ACTRN12615000374561
• Lead Sponsor: fuk University School of Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-04-23
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 150

Inclusion Criteria

male factor infertility
without prior history of testicular surgery
age between 18-40
with partner age of 18-40
normal karyotype

Exclusion Criteria

-Subjects with prior testicular surgery
-Subjects undergoing assisted reproductive techniques with genetic screening
-Subjects under age 18 or above 40
-Subjects under medication resulting with altered sperm production
-Subjects with severe metabolic disorder

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Is to investigate the impact of seminal plasma Galectin-3 levels on sperm parameters in terms of total count per mL, motility and morphology in subjects undergoing assisted reproductive technology (ART). Association between Galectin levels and spermatogenesis will be determined. [Baseline Galectin-3 levels will be determined at the time of assisted reproductive services along with sperm evaluation of subjects.]

Secondary Outcome Measures

Name	Time	Method
To determine the association between seminal plasma Galectin-3 levels and cycle outcomes of patients undergoing assisted reproductive techniques (ART); briefly:<br>Subjects will be divided into groups according to their sperm counts/mL. Following appropriate distribution of all cases, study groups will be compared according to their baseline sperm parameters and IVF cycle outcomes in terms of embryological data, embryo grading, biochemical pregnancy, clinical-ongoing pregnancy and abortion rates. Assessment of outcomes will be considered following completion of all IVF/ICSI cycles till pregnancy test. Baseline Galectin-3 levels will be determined at the time of assisted reproductive services. [Assessment of outcomes will be considered following completion of all IVF/ICSI cycles till pregnancy test. ]