Improvement of Mood and Cognition in patients with chronic hepatitis C infection after specific treatment for HCV.
Not Applicable
- Conditions
- Health Condition 1: K739- Chronic hepatitis, unspecified
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All patients with viremic chronic hepatitis C
Compensated Cirrhosis
Exclusion Criteria
Current overt hepatic encephalopathy or during the last 1 month, TIPS (transjugular intra-hepatic porto-systemic shunt), elective surgery planned within the next 8 weeks, unable to give informed consent, HIV, chronic respiratory insufficiency, renal failure (serum creatinine >= 2.0 mg/l, hepatocellular carcinoma, patient with other neurological disease and intake of sedatives, antidepressants, benzodiazepines, or benzodiazepines-antagonists (flumazenil, neuromuscular blocking agents.
Pregnant Patients
Pediatric Patients
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cognitive performance by (1) Computerized battery: Reaction times, simple and choice, visual memory, Number connection test, and Inhibitory Control Test and (2) Paper-and-pencil tests: Psychometric hepatic encephalopathy score (PHES), Indian Version. <br/ ><br>HRQOL by SF-36 <br/ ><br>Timepoint: Time Frame: 0 days, and 90 days after treatment completion
- Secondary Outcome Measures
Name Time Method Beckâ??s Depression Inventory (BDI)Timepoint: Time Frame: 0 days, and 90 days after treatment completion;Generalized anxiety disorder (GAD 7 score)Timepoint: Time Frame: 0 days, and 90 days after treatment completion;Montreal Cognitive assessment Score (MoCA Score)Timepoint: Time Frame: 0 days, and 90 days after treatment completion;Psychometric hepatic encephalopathy Score (PHES)Timepoint: Time Frame: 0 days, and 90 days after treatment completion