Dose and Response of Dietary Nitrate in Healthy and Active Men
- Conditions
- Healthy
- Interventions
- Dietary Supplement: sodium nitrateDietary Supplement: Beetroot juice
- Registration Number
- NCT01961427
- Lead Sponsor
- Swiss Paraplegic Research, Nottwil
- Brief Summary
It was shown by some researchers that dietary nitrate such as beet root juice can lower oxygen consumption in men and act as a performance enhancing supplement.
It was not shown, what the optimal dosage is and if there is any difference in oxygen consumption comparing beet root juice and inorganic nitrate.
Therefore, the aim of the study is to conduct a study ingesting different sodium nitrate and beet root juice dosages. We would measure nitrate and nitrite concentrations in the blood at different time points and the subjects have to perform an exercise test measuring oxygen consumption 3 hours after the ingestion of nitrate.
- Detailed Description
1. The subjects have to ingest 7 different dosages of either beetroot juice or sodium nitrate on seven different occasions. Every hour a blood withdrawal is taken to measure nitrate and nitrite concentration in the blood.
2. The subjects have to ingest 7 different dosages of either beetroot juice or sodium nitrate on seven different occasions. Three hours after the intake of the supplement the subjects have to perform an exercise test on a bicycle. They have to cycle 5 min at 50% of maximal oxygen consumption and 8min at 80% of maximal oxygen consumption separated by a 5min break. Oxygen consumption would be measured during the whole exercise test. Blood withdrawal is taken before the ingestion, after 3 hours and after the test.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 21
- age 18 to 45
- healthy active men
- non-smoking
- medication intake during study phase
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- FACTORIAL
- Arm && Interventions
Group Intervention Description sodium Nitrate (6mmol) sodium nitrate ingestion of inorganic nitrate (6mmol solution) sodium nitrate 3mmol sodium nitrate ingestion of inorganic nitrate (3mmol solution) Beetroot juice (12mmol) Beetroot juice ingestion of 170ml of concentrated beetroot juice (12mmol) Beetroot juice (3mmol) Beetroot juice Ingestion of 42.5ml of concentrated beetroot juice (3mmol) sodium nitrate (0mmol) sodium nitrate Ingestion of water as a placebo sodium Nitrate 12mmol sodium nitrate Ingestion of a solution of inorganic nitrate, dosage: 12mmol beetroot juice (6mmol) Beetroot juice ingestion of 85ml concentrated beetroot juice (6mmol)
- Primary Outcome Measures
Name Time Method oxygen consumption 30min Oxygen consumption during exercise protocol
- Secondary Outcome Measures
Name Time Method Blood pressure 6 hours every hour, blood pressure is measured.
Nitrate and nitrite concentration 6 hours every hour for the six hours after the ingestion of dietary/inorganic nitrate, nitrate and nitrite concentration in the blood is analyzed.
oxygen saturation 6 hours every hour oxygen saturation is measured.
Rating of perceived exertion (RPE) during the 7 weeks of study phase RPE is measured after the low-intensity exercise performance and after the submaximal exercise performance.
Heart rate during the 7 weeks of study phase Heart rate is measured before the ingestion, before the exercise test and during the exercise test. resting heart rate is additionally measured every hours after the intake of dietary/inorganic nitrate.
Trial Locations
- Locations (1)
Swiss Paraplegic Centre
🇨ðŸ‡Nottwil, Lucerne, Switzerland